CEPHAZOLIN/CEFAZOLIN

Indications & Dose:

 Infections of the lower respiratory tract, urinary tract, biliary tract, and genitourinary tract; infections of the skin and skin structure, bones and joints; endocayditis, prostatitis, surgical prophylaxis, septicemia

DOSE

Adult

Usually 1-4g daily i.m. or i.v. in 2-3 divided doses.

• Life-threatening infections: IM/IV 1-2 g q6h

• Mild/moderate infections: IM/IV 500 mg-1gm q8h

• UTI: 500mg-1gm 12 hourly

• Surgical prophylaxis: IM/IV 1 g 1/2-1 hr prior to surgery then 500 mg-1 g q6-8 hr x 24 hr postoperatively

Dosage reduction appropriate in renal impairment (CrCI <50 ml/min)

Child >l mo

• Life-threatening infections: IM/IV 100 mg/kg in 3-4 equal doses

• Mild/moderate infections: IM/IV 25-50 mg/kg in

3-4 equal doses

Below 1 month not recommended

Contraindications:

 Infants < 1 mo

Side Effects:

CNS: Chills, dizziness, fever, headache, paresthesia, weakness

GI: Abdominal pain, anorexia, bleeding; diarrhea, glossitis, increased LFTs, nausea, vomiting, pseudomembranous colitis

GU: Candidiasis, nephrotoxicity, pruritus, vaginitis

HEME: Bone marrow suppression, eosinophilia; hemolytic anemia, lymphocytosis

SKIN: Dermatitis, rash, urticaria 

Cautions:

Precautions:

Hypersensitivity to penicillins, renal disease 

Interaction:

Drugs

Aminoglycosides: Additive nephrotoxicity

Ethanol: Disulflozm-like reaction

Chloramphenicol: Inhibits antibacterial activity of cefazolin

Loop diuretics: Increased nephrotoxicity

Oral Anticoagulants: Additive hypoprothrombinemia 

Warnings:

Adverse Effects:

Lactations:

Low milk concentrations

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: