Rheumatoid Arthritis

Alternate Name:

Test:

Rheumatoid factor (+ in 70%), S,HLA-DR4 (+),synovial fluid (AB), S.gamma-globulin (H), S.ANA (H in 30%), Hb (L), ESR (H), S.CRP (H), X-rays of hands and feet (AB)

Sign:

Boutonniere deformity, muscular atrophy, hepa- tomegaly, spider naevi, splenomegaly (Fe(ty's syn.)

Dd:

Osteoarthritis, gout, chondrocalcinosis, SLE, psoriasLs, gonorrhoea, sarcoldosis, ulcerative colitis, Reiter's syn., Crohn's disease, malignancies, rheu­matic fever, ankylosing spondylitis, viraernias, trauma

Phys:

Chronic inflammation of synovial membranes (particularly in hands and feet), of unknown aetiol­ogy. Rheumatoid factor not diagnostic. Juvenile form known as Still's disease