Polyarteritis Nodosa [PAN]

Alternate Name: Perlarteritis Nodose

Test:

Open biopsy of symptomatic site (+), WCC' (H), B.eosinophils (H), ESR (H), S.CRP (H), &ALP (H), U.protein & blood (+ or -), renal biopsy (AB)

Sign:

Hepatomegaly, splenomegaly, large kidney, hy­pertension, tachycardia, petechiae, cardiac ar­rhythrnias, neurological lesions

Dd:

Allergic angiitis; granulomatosis, rheumatoid ar-thritis, Gooctpasture's syn., SLE, necrOtising vasculitis, endocarditis, leptospirosis, transverse myelitis

Phys:

Necrotic nodules form along major arteries, par­ticularly at junctions. Secondary glomerulonephri­tis and liver involvement common. Aetiology un­known