Pernicious Anaemia

Alternate Name: Megalobiastic Anaemia

Test:

Schilling test (AB), S.vit. 1312 (L), B.intrinsic fact&autoantibodies (+), fib (L), WCC (L), platelets (14, bone marrow biopsy (rnegaloblastic), S.folic acid (L or N), S.bilirubin (N or H), S:LDH (H), LFT (AB), gastric pH (H), S.parietal cell antibodies (+)

Sign:

Dd:

Folic acid deficit, other anaemias, hepatic dia- ease

Phys:

There are causes of megaioblastic anaemia other than pernicious anaemia. Due to lack of intrinsic factor in the stomach and subsequent failure of vit.B,,absorption