Multiple Myeloma

Alternate Name:

Test:

S.electrophoresis (abnormal spike), marrow aspi-rate (myeloma cells), Hb (L),132-microglobulin (H), ESR (H), S.protein (H & AB), WCC (N), U.Bence-Jones protein (+), S.creatinine (H), S.calcium (H), S.globulin (VH), S.gamma-globulin (L excl. spike), S.urea (H)

Sign:

Dd:

Leukaemia, infection, renal failure, skeletal dis-ease, sarcoma, secondary carcinoma, hyperpar­athyroidism, cirrhosis

Phys:

Plasma cell neoplasia. Anaemia is due to bone marrow replacement. An abnormal gamma-glob­ulin is found in serum and urine due to an immune response to abnormal plasma cells with suppres­sion of normal gamma-globulin