Hand-Schueller-Christian Disease

Alternate Name:

Test:

Granuloma microscopy (foam cells present),B.eosinophils (VH), Hb (L), platelets (L), S.che­lesterol (N)

Sign:

Exophthalmos, polyuria, splenomegaly, hepato-megaly

Dd:

Letterer-Siwe disease, histiocytosis X, diabetes insipidus, hepatic failure, lymphOmas, hypogo­nadism, CCF

Phys:

Excessive tissue :retention of cholesterol forms foam cells in granulornatous lesions of skin, liver, bones and gut