| Product | Precaution | Interaction | Onset | Severity |
|---|---|---|---|---|
| MIDAZOLAM | Concurrent use of MIDAZOLAM and GRAPEFRUIT JUICE may result in increased bioavailability and pharmacodynamic effects of midazolam. | GRAPEFRUIT JUICE | Rapid (within 24 hours) | Moderate (mayexacerbate patient’s condition) |
| MIDAZOLAM | Concurrent use of CAFFEINE and MIDAZOLAM may result in reduced sedative and anxiolytic effects of midazolam. | CAFFEINE | Rapid (within 24 hours) | Minor (little if any clinical effect) |
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