Indications & Dose:

Adults infants (aged 3 months and older) children and adolescents for the treatment of the following infections:

Complicated Intra-Abdominal Infection: (in combination with metronidazole) Complicated Urinary Tract Infection, including Pyelonephritis (cUTI)Hospital-acquired Pneumonia (HAP), including ventilator associated pneumonia (VAP) Infections due to aerobic Gram-negative organisms in patients with limited treatment options.

Treatment of adult patients with bacteremia that occurs in association with or is suspected to be associated with cIAI, cUTI or HAP/VAP.

Dosage/Direction for Use

Infections due to aerobic Gram-negative organisms in adults and pediatric patients aged 3 months and older with limited treatment options only after consultation with a physician with appropriate experience in the management of infectious diseases.

Adults with Creatinine Clearance (CrCL and 50 mL/min): 1 vial where each vial contains 2 g ceftazidime and 0.5 g avibactam administered by intravenous (IV) over 2 hours. Treatment is repeated every 8 hours.

Method of administration: Intravenous use.

Adults by intravenous infusion over 2 hours in an appropriate infusion volume.

Contraindications:

Hypersensitivity

Use In Pregnancy Lactation

Pregnancy: There is limited clinical data from the use of ceftazidime-avibactam in pregnant women.

Ceftazidime-avibactam should not be used during pregnancy unless clearly necessary and only ifthe potential benefit outweighs the possible risk.

Cautions:

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Precautions:

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Interaction:

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Warnings:

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Adverse Effects:

The most common: N nausea and diarrhea.

Lactations:

There are no data on human milk excretion.

Special Precautions:

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Counselling:

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Side Effects Or Adverse Reactions:

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Patient And Carer Advice:

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