Indications & Dose:

Treatment of multiple myeloma that has progressed despite the use of at least one therapy and where the patient has already had or is unable to have haematopoietic stem cell transplantation (either as monotherapy or in combination with pegylated liposomal doxorubicin or dexamethasone) Treatment of previously untreated multiple myeloma in patients who are not eligible for high-dose chemotherapy with haematopoietic stem cell transplantation (in combination with melphalan and prednisolone) Induction treatment of previously untreated multiple myeloma in patients who are eligible for high-dose chemotherapy with haematopoietic stem cell transplantation (in combination with dexamethasone or with dexamethasone and thalidomide) .

BY INTRAVENOUS INJECTION OR SUBCUTANEOUS INJECTION Adult: (consult local protocol)

Contraindications:

Acute diffuse infiltrative pulmonary disease

. pericardial disease

Cautions:

Amyloidosis . cardiovascular disease . consider antiviral prophylaxis for herpes zoster infection . dehydration . history of syncope . pulmonary disease (discontinue if interstitial lung disease develops).risk factors for seizures .risk of neur-opathy-consult product literature.

Precautions:

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Interaction:

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Warnings:

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Adverse Effects:

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Lactations:

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Special Precautions:

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Counselling:

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Side Effects Or Adverse Reactions:

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Patient And Carer Advice:

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