Indications & Dose:

Treatment of chronic lymphocytic leukaemia | Treatment of non-Hodgkins lymphoma | Treatment of multiple myeloma

BY INTRAVENOUS INFUSION

Adult: (consult local protocol)

Contraindications:

Jaundice . low leucocyte count. low platelet count. major surgery less than 30 days before start of treatment. severe bone marrow suppression

Cautions:

Avoid in acute porphyrias : cardiac disorders-monitor serum potassium and ECG

Precautions:

-

Interaction:

-

Warnings:

Effective contraception is required during treatment in men or women and for 6 months after treatment in men. See also Pregnancy and reproductive function in Cytotoxic drugs

PREGNANCY Avoid

BREAST FEEDING Discontinue breast-feeding.

HEPATIC IMPAIRMENT Consider a 30% dose reduction in moderate impairment. Avoid in severe impairment.

RENAL IMPAIRMENT No information available on use in patients with creatinine clearance less than 10 mL/minute.

ANTINEOPLASTIC DRUGS ANTI-ANDROGENS

Adverse Effects:

-

Lactations:

-

Special Precautions:

-

Counselling:

-

Side Effects Or Adverse Reactions:

-

Patient And Carer Advice: