Indications & Dose:

Treatment of previously treated anaplastic lymphoma kinase (ALK) positive advanced non-small cell lung cancer

BY MOUTH

Adult: 250 mg twice daily for dose adjustments due to side-effect consult product literature

Contraindications:

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Cautions:

History of diverticulitis (risk of gastrointestinal perforation-discontinue treatment if gastrointestinal perforation occurs). metastases of gastrointestinal tract (risk of gastro-intestinal perforation-discontinue treatment if gastrointestinal perforation occurs). patients with susceptibility to QTprolongation (including bradycardia, history of cardiac disease, concomitant use of drugs that prolong QT interval and electrolyte disturbances) periodic renal monitoring required .risk of gastro-intestinal perforation-discontinue treatment if gastrointestinal perforation occurs . vision disorders reported-consider full ophthalmological evaluation if vision disorder worsens or persists.

Fatal interstitial lung disease and pneumonitis Fatal interstitial lung disease and pneumonitis reported (monitor patients with pulmonary symptoms withdraw treatment if suspected and permanently discontinue treatment if diagnosed).

Precautions:

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Interaction:

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Warnings:

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Adverse Effects:

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Lactations:

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Special Precautions:

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Counselling:

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Side Effects Or Adverse Reactions:

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Patient And Carer Advice:

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