Indications & Dose:

To produce appetite suppression for the purpose of attaining weight loss in the treatment of patients with obesity.

BY MOUTH

10 mg administered once daily with or without food. If there is inadequate weight loss, the dose may be titrated after four weeks to a total of 15 mg once daily. The 5 mg dose should be reserved for patients who do not tolerate the 10 mg dose. Blood pressure and heart rate changes should be taken into account when making decisions regarding dose titration

Contraindications:

Psychiatric conditions as bulimia nervosa, anorexia nervosa, serious depression or pre-existi. Hypersensitivity to the drug or any of the inactive ingredients. Patients below 18 and above 65 years of age.Concomitant treatment with a MAO inhibitor, antidepressant or other centrally active drugs, particularly other anoretics. History of peripheral arterial disease.Hypertension that is not sufficiently controlled (e.g.145/90 mmHg), caution in controlled hypertension Existing pulmonary hypertension. Existing damage on heart valves, coronary heart disease, congestive heart failure, serious arrhythmias, previous myocardial infarction. A history of coronary artery disease (e.g angina, history of myocardial infarction), congestive heart failure, tachycardia, peripheral arterial occlusive disease, arrhythmia or cerebrovascular disease (stroke or transient ischemic attack. Stroke or transient ischemic attack (TIA). Hyperthyroidism (overactive thyroid gland). Closed angle glaucoma. Seizure disorders. Enlargement of the prostate gland with urinary retention (relative contraindication). Pheochromocytoma. Pregnant and lactating women (relative contraindication).

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