Indications & Dose:

Prophylaxis of venous thromboembolism following knee replacement surgery

BY MOUTH

Adult: 2.5 mg twice daily for 10–14 days, to be started 12–24 hours after surgery Prophylaxis of venous thromboembolism following hip replacement surgery

BY MOUTH

Adult: 2.5 mg twice daily for 32–38 days, to be started 12–24 hours after surgery

Treatment of deep-vein thrombosis | Treatment of pulmonary embolism

BY MOUTH

Adult: Initially 10 mg twice daily for 7 days, then maintenance 5 mg twice daily

Prophylaxis of recurrent deep-vein thrombosis |Prophylaxis of recurrent pulmonary embolism

BY MOUTH

Adult: 2.5 mg twice daily, following completion of 6 months anticoagulant treatment Prophylaxis of stroke and systemic embolism in nonvalvular atrial fibrillation

and at least one risk factor such as previous stroke or transient ischaemic attack, symptomatic heart failure, diabetes mellitus, hypertension, or age 75 years

BY MOUTH

Adult 18–79 years: 5 mg twice daily

Adult 80 years and over (body-weight up to 61 kg): 2.5 mg twice daily

Adult 80 years and over (body-weight 61 kg and above): 5 mg twice daily continued

Contraindications:

Active bleeding . malignant neoplasms . oesophageal varices . recent brain surgery . recent gastro-intestinal ulcer . recent intracranial haemorrhage . recent 

ophthalmic surgery . recent spine surgery . significant risk of major bleeding . vascular aneurysm

Cautions:

CAUTIONSAnaesthesia with postoperative indwelling epidural catheter (risk of paralysis—monitor neurological signs and wait 20–30 hours after apixaban dose

before removing catheter and do not give next dose until at least 5 hours after catheter removal) . prosthetic heart valve (efficacy not established) . risk of

bleeding

Precautions:

Interaction:

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: