Indications & Dose:

Antidote for acetaminophen overdose; mucolytic: adjuvant therapy for abnormal, viscid, or inspissated mucus secretions in chronic bronchopulmonary disease; diagnostic bronchial scans (bronchograms, bronchospirometry, bronchial wedge catheterization); keratoconjunctivitis sicca* (as ophthalmic solution); bowel obstruction due to meconium ileus* (as an enema)

DOSE

Dissolve granules in water before administration.

• Acetaminophen toxicity: PO 140 mg/kg, then 70 mg/kg q4h x 17 doses to total of 1330 mg/kg; (dilute 20% solution to concentration of 5 %; dilutions should be freshly prepared and utilized within 1 hr)

Adults

Respiratory conditions, 1 sachet 3 times daily. Cystic fibrosis, acute cases; maintenance: 1 or 2 sachets three times daily.

Children

Respiratory conditions, under 2 years, 1 sachet daily; 2-6 years, 1 sachet twice daily; over 6 years, same as adult. Cystic fibrosis: acute cases, maintenance: under 2 years, 1/2–1 sachet three times daily; 2-6 years, 1 sachet three times daily; over 6 years, 1 or 2 sachets three times daily

Contraindications:

Cautions:

Precautions:

Asthma, hepatic disease, renal disease, COPD, alcoholism

Interaction:

Warnings:

Adverse Effects:

Lactations:

Pregnancy category B

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Chills, dizziness, drowsiness, fever, headache
EENT: Rhinorrhea
GI: Anorexia, nausea, stomatitis, vomiting
RESP: Bronchospasm, chest tightness
SKIN: Clamminess, fever, rash, urticaria

Patient And Carer Advice: