Indications & Dose:

Hypertension, CHF (left ventricular dysfunction),* myocardial infarction,* diabetic nephropathy l

• BY MOUTH

Adult: 50mg once daily, may be increased to 100mg once daily.

Elderly: Over 75 years initially 25mg once daily.

Children: Not recommended.

Contraindications:

Hypersensitivity to any of the component, Pregnancy & breast-feeding

Cautions:

Precautions:

Angioedema (associated with aspirin and/or penicillin allergy), aortic or mitral valve stenosis, biliary cirrhosis or biliary obstruction, breast feeding period, coronary artery disease, elderly patients, hepatic dysfunction (adjust dose), hypertrophic cardiomyopathy, hypotension (sodium or volume depleted patients), pregnancy, renal artery stenosis, solitary kidney, or congestive heart failure

Interaction:

Drugs

FIuconazole: Decreased conversion to active metabolite (CYP2C9 inhibition), loss of antihypertensive effects

Lithium: Increased renal lithium reabsorption at the proximal tubular site due to the natriuresis associated with the inhibition of aldosterone secretion; increased risk of lithium toxicity

Rifampin: Induced metabolism of losartan and metabolite, resulting in a decrease in the area under the concentration-time curve (AUC) and half-life of both compounds and reduced losartan efficacy

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: