Indications & Dose:

Prophylactically to provide passive immunity to hepatitis B infection in individuals exposed to HBV or HBsAg-positive materials (blood plasma, serum). Also as postexposure prophylaxis after bite or percutaneous exposure, ingestion, direct mucous, membrane contact, sexual or intimate contact, and in neonates born to HBsAg-positive women.

DOSE

Following exposure to HBsAg: 

Adults

1000-2000 i.u. i.m. 

Children

 32-48 i.u./kg body wt. This should be administered within 7 days (preferably within 48 hours) after exposure to HBsAg. 

Neonates: Initial dose is 100-200 i.u. The first dose should be administered within 5 days after birth. The booster dose should be 32-48 i.u./kg of body wt. between 2 & 3 months after initial dose. specific immunoglobulin A (IgA) deficiency

Contraindications:

CONTRAINDICATION & PRECAUTIONS CAUTIOUS

History of systemic allergic reactions to immune globulin, thrombocytopenia or bleeding disorders. HBsAg-positive individuals, patients with 

Cautions:

Precautions:

Interaction:

Drugs May interfere with immune response to Live Virus Vaccine (measles/mumps/rubella/poliovirus)

Warnings:

Adverse Effects:

Usually infrequent and mild.

Skin Hypersensitivity: urticaria, rash, angioedema, pruritus, erythema, sensitization (following large or repeated doses), anaphylaxis (rare).

Local: muscle stiffness; pain, tenderness, swelling, erythema of injection site.

Other: nausea, faintness, fever, dizziness, malaise, lassitude, body and joint pain, leg cramps.

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: