Teneligliptin

Indications & Dose:

As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. Usually, teneligliptin is used as monotherapy in patients for whom metformin is inappropriate due to contraindications or intolerance. Further, teneligliptin can also be used in combination with metformin or other antidiabetic medications.

oral 

adults.

20 mg to be administered orally once daily without regard to meals. If efficacy is insufficient, the dose may be increased up to 40 mg once daily.  

Contraindications:

Known hypersensitivity to teneligliptin or to any component of this formulation.

Type 1 diabetic patients,

Diabetic coma or history of diabetic coma.

Severe ketosis.

Patients with severe infection, surgery, or trauma (preferably insulin to be used to control

blood glucose level in these conditions).

Side Effects:

The most common adverse reactions reported with teneligliptin are hypoglycemia and constipation. Other adverse reactions reported with the use of teneligliptin may include,

General: Fatigue, headache, dizziness, pyrexia.

Gastrointestinal Disorders: Intestinal obstruction, abdominal bloating, abdominal discomfort, nausea, vomiting, abdominal pain, flatulence, stomatitis, gastric polyps, colon polyps, duodenal ulcer, reflux esophagitis, diarrhea, loss of appetite, acute pancreatitis.

Liver: Increased AST (SGOT), increased A L T (SGPT), and increased GTP

Kidney and Urinary System: Proteinuria, positive ketone bodies in urine.

Skin and Subcutaneous Tissue Disorders: Eczema, rash, itching, allergic dermatitis.

Respiratory System: Allergic rhinitis, nasopharyngitis, pneumonia.

PREGNANCY: Avoid.

Lactating Women: Avoid

Paediatric Patients: not recommended for use in paediatric patients.

Geriatric Patients: with caution 

Renal Impairment Patients: Teneligliptin can be used in diabetes patients with renal impairment, including those on hemodialysis, without the need for dose adjustment.

Cautions:

Precautions:

Interaction:

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: