Decitabine

Indications & Dose:

Treatment of newly diagnosed acute myeloid leukaemia in patients over 65 years of age who are not candidates for standard induction chemotherapy

BY INTRAVENOUS INFUSION

Elderly: (consult local protocol)

Contraindications:

Side Effects:

Common or very common Diarrhoea . epistaxis . headache

Uncommon Acute febrile neutrophilic dermatosis

Frequency not known Alopecia . bone-marrow suppression . extravasation . hyperuricaemia . nausea . oral mucositis . thromboembolism .tumour lysis syndrome . vomiting

Cautions:

1. History of severe congestive heart failure . history of unstable cardiac disease

Precautions:

Interaction:

Warnings:

Men must avoid fathering a child during and for 3 months after treatment.

PREGNANCY Avoid (teratogenic in animal studies).

BREAST FEEDING Discontinue breast-feeding.

HEPATIC IMPAIRMENT Manufacturer advises caution

RENAL IMPAIRMENT Manufacturer advises caution

information available.

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: