Dexmedetomidine Hydrochloride

Indications & Dose:

Maintenance of sedation during intensive care

BY INTRAVENOUS INFUSION

Adult: 0.7 microgram/kg/hour adjusted according to response usual dose 0.2-1.4 micrograms/kg/hour

IMPORTANT SAFETY INFORMATION

Dexmedetomidine should only be administered by or under the direct supervision of personnel experienced in its use with adequate training in anaesthesia and airway management.

Contraindications:

Acute cerebrovascular disorders . second- or third-degree AV block (unless pacemaker fitted). uncontrolled hypotension

Side Effects:

Common or very common Agitation . blood pressure changes . bradycardia . changes in blood sugar. dry mouth . hyperthermia . myocardial infarction . myocardial ischaemia . nausea .tachycardia . vomiting

Uncommon Abdominal distension . AV block . decreased cardiac output. dyspnoea . hallucination . hypoalbuminaemia . metabolic acidosis .thirst

PREGNANCY Avoid unless potential benefit outweighs risk-toxicity in animal studies.

BREAST FEEDING Avoid unless potential benefit outweighs risk

HEPATIC IMPAIRMENT Dose reduction may be required.

Manufacturer advises caution.

MONITORING REQUIREMENTS

Monitor cardiac function.

Monitor respiratory function in non-intubated patients.

DIRECTIONS FOR ADMINISTRATION To be diluted before use. For intravenous infusion given continuously in Glucose 5% or Sodium chloride 0.9%, dilute to a concentration of 4 micrograms/mL.

Cautions:

Abrupt withdrawal after prolonged use . bradycardia . ischaemic heart disease . malignant hyperthermia . severe cerebrovascular disease (especially at higher doses) . severe neurological disorders . spinal cord injury

Precautions:

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Interaction:

Anesthetics, sedatives, hypnotics, opioids: Enhancement of pharmacodynamic effects. Reduction in dosage of Dexmedetomidine or the concomitant medication may be required.

Warnings:

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Adverse Effects:

-

Lactations:

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Special Precautions:

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Counselling:

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Side Effects Or Adverse Reactions:

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Patient And Carer Advice:

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