Atezolizumab

Indications & Dose:

Urothelial carcinoma (specialist use only) I Non-small cell lung cancer (specialist use only) I Small cell lung cancer (specialist use only) I Breast cancer (specialist use only)

BY INTRAVENOUS INFUSION

Adult: (consult product literature)

Contraindications:

Side Effects:

Common or very common Abdominal pain . appetite decreased . arthralgia . ascites . asthenia . chills . cough . cystitis . cytokine release syndrome . diarrhoea . dysphagia . dyspnoea . electrolyte imbalance . euthyroid sick syndrome . eye disorders . fever . gastrointestinal disorders . goitre . hepatic disorders . hyperglycaemia . hypersensitivity . hypotension . hypothyroidism . hypoxia . increased risk of infection . influenza like illness . infusion related reaction . myalgia . myxoedema . nasal congestion . nausea . oesophageal varices . oesophageal varices haemorrhage . oropharyngeal complaints . pain . radiation pneumonitis . respiratory disorders . skin reactions . skin ulcer . throat irritation . thrombocytopenia . thyroid disorder . thyroiditis . toxic epidermal necrolysis . ulcerative colitis . vomiting

Uncommon Adrenal hypofunction . connective tissue disorders . diabetes mellitus . diabetic ketoacidosis . hyperthyroidism . ketoacidosis . meningitis . muscle abscess . myopathy . nerve disorders . pancreatitis . photophobia

Rare or very rare Hypophysitis . myocarditis . nephritis . neuromuscular dysfunction . temperature regulation disorder

CONCEPTION AND CONTRACEPTION Manufacturer advises effective contraception in women of childbearing potential, during treatment and for 5 months after stopping treatment. See also Pregnancy and reproductive function in Cytotoxic drugs

PREGNANCY Manufacturer advises avoid unless essential-no information available. See also Pregnancy and reproductive function in Cytotoxic drugs

BREASTFEEDING Manufacturer advises avoid-no information available.

MONITORING REQUIREMENTS Manufacturer advises . monitor for signs and symptoms of infusion- and immune-related reactions-consult product literature.

Cautions:

Abnormal thyroid function-manufacturer advises to consider appropriate treatment . patients may need pre-medication to minimise the development of infusion-related reactions-consult product literature

Precautions:

Interaction:

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Lactations:

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Counselling:

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