Tapentadol

Indications & Dose:

Moderate to severe acute pain which can be managed only with opioid analgesics

BY MOUTH 

Adult: Initially 50 -100mg every 4–6 hours, adjusted\ according to response, maximum 700mg in the first24 hours, during the first 24 hours of

treatment, an additional dose of 50 mg may be taken 1 hour after theinitial dose, if pain control not achieved; maximum 600 mg per day

Severe chronic pain

BY MOUTH 

Adult: Initially 50-100 mg every 12 hours, adjusted according to response; maximum 500 mg per day

Contraindications:

Side Effects:

Abdominal discomfort .anxiety .ataxia .decreased appetite . diarrhoea.dysarthria .dyspepsia.hypoaesthesia. malaise .muscle spasms .

paraesthesia.seizures .tremor .weight loss

Cautions:

Precautions:

Interaction:

Warnings:

Adverse Effects:

Lactations:

BREAST FEEDING Avoid—no information available.

HEPATIC IMPAIRMENT For immediate-release tablets, initial max. daily dose 150 mg; for modified-release tablets, initial max. daily dose

50mg.

RENAL IMPAIRMENT No dose adjustment needed in mild or moderate impairment. Avoid in severe impairment; opioid effects increased and

prolonged and increased cerebral sensitivity occurs

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: