Brinzolamide

Indications & Dose:

Reduction of intra-ocular pressure in ocular hypertension and open-angle glaucoma either as adjunct to betablockers or

prostaglandin analogues or used alone in patients unresponsive to beta-blockers or if betablockers contra-indicated

TO THE EYE

Adult: Apply twice daily, then increased if necessary up to 3 times a day

Contraindications:

Contra-indicated if history of sulfonamide hypersensitivity

Side Effects:

Common or very common Corneal erosion .cornealoedema . dry mouth . headache .ocular disturbances . photophobia.reduced visual acuity .

taste disturbances Uncommon Alopecia .amnesia .bradycardia .chest pain . cough .decreased libido . depression .diarrhoea .dizziness .drowsiness

.dyspepsia.dyspnoea .epistaxis .erectile dysfunction . flatulence .malaise .nasal dryness . nausea .nervousness .oesophagitis .oralhypoaesthesia

and  paraesthesia . palpitation .paraesthesia .pharyngitis.renal pain . sinusitis .sleep disturbances . throat irritation . tinnitus .upper respiratory

tract congestion . vomiting Frequency not known Arrhythmia .asthma .dermatitis .erythema .hypertension .peripheraloedema . rhinitis

.tachycardia .tremor .vertigo

SIDE-EFFECTS

Systemic absorption can rarely cause sulfonamide-like side-effects and may require discontinuation if severe.

Cautions:

Renal tubular immaturity or abnormality .

systemic absorption follows topical application

Precautions:

Interaction:

Warnings:

Adverse Effects:

Lactations:

 PREGNANCY Avoid 

BREAST FEEDING Use only if benefit outweighs risk.

HEPATIC IMPAIRMENT Avoid.

RENAL IMPAIRMENT Avoid if eGFR less than 30 mL/minute/1.73m2.

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: