Cinacalcet

Indications & Dose:

Treatment of infertility in women with proven hypopituitarism or who have not responded to clomifenen| Superovulation

treatment for assisted conception (such as in vitro fertilisation)

BY MOUTH

Adult: Initially 30 mg once daily, dose to be adjusted every 2–4 weeks; maximum 180 mg per day

Treatment of hypercalcaemia in parathyroid carcinoma | Primary hyperparathyroidism in patients wheremparathyroidectomy is

inappropriate

BY MOUTH

Adult: Initially 30 mg twice daily (max. per dose 90 mgm 4 times a day), dose to be adjusted every 2–4 weeks according to response

Contraindications:

Side Effects:

Common or very commonAnorexia .asthenia .dizziness .myalgia .nausea .paraesthesia .rash .reduced testosterone concentrations . vomiting

Uncommon Diarrhoea .dyspepsia .seizures Frequency not known Allergic reactions .angioedema .heart failure . hypotension

Cautions:

Treatment should not be initiated in patients with hypocalcaemia

Precautions:

Interaction:

Warnings:

Adverse Effects:

Lactations:

PREGNANCY Only if potential benefit outweighs risk—no information available.

BREAST FEEDING Avoid—present in milk in animal studies.

HEPATIC IMPAIRMENT Caution in moderate to severe impairment. Monitor closely in hepatic impairment especially when increasing dose.

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: