Lurasidone hydrochloride

Indications & Dose:

Schizophrenia

BY MOUTH

Adult: Initially 37 mg once daily, increased if necessary  up to 148 mg once daily

Schizophrenia when given with concomitant moderate CYP3A4 inhibitors (e.g. diltiazem, erythromycin,mfluconazole, and verapamil)

BY MOUTH

Adult: Initially 18.5 mg once daily (max. per dose 74 mg once daily)

Contraindications:

Side Effects:

Common or very commonAnxiety .musculoskeletal stiffness UncommonCatatonia .decreased appetite . dysarthria .dysuria .hotflush . myalgia

.nightmares Frequency not known Angina .AV block .bradycardia .dysphagia .panic attacks . pruritus .suicidalbehaviour. vertigo

Cautions:

High doses in elderly .susceptibility to QTinterval prolongation

Precautions:

Interaction:

Warnings:

Adverse Effects:

Lactations:

PREGNANCY Use only if potential benefit outweighs risk—limited information available.

HEPATIC IMPAIRMENT Initially 18.5mg once daily, up to max. 74mg once daily in moderate impairment. Use with caution in severe

impairment—initially 18.5mg once daily, up to max. 37mg once daily.

RENAL IMPAIRMENT Initially 18.5mg once daily, up to max. 74mg once daily if eGFR less than 50 mL/minute/1.73m2. Manufacturer advises

use only if potential benefit outweighs risk if eGFR less than 15 mL/minute/1.73m2.

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: