Phenylephrine Hydrochloride

Indications & Dose:

Acute hypotension

• BY SUBCUTANEOUS INJECTION, OR BY INTRAMUSCULAR INJECTION

Adult: Initially 2–5 mg, followed by 1–10 mg, after at least 15 minutes if required 

• BY SLOW INTRAVENOUS INJECTION

Adult: 100–500 micrograms, repeated as necessary after at least 15 minutes 

• BY INTRAVENOUS INFUSION

Adult: Initially up to 180 micrograms/minute, reduced to 30–60 micrograms/minute, adjusted according to response

Contraindications:

 Hypertension . severe hyperthyroidism

Side Effects:

hypertension, headache, bradycardia, arrhythmia, peripheral ischaemia, anorexia, nausea, vomiting, hypoxia, dysnea, insomnia, confusion, anxiety, tremor, urinary retention.

Cautions:

coronary, mesenteric, or peripheral vascular thrombosis; following myocardial infarction, Prinz metal’s variant angina, hyperthyroidism, diabetes mellitus; hypoxia or hypercapnia; uncorrected hypovolaemia; elderly; extravasation at injection site may cause necrosis; interactions

PREGNANCY Avoid if possible; malformations reported following use in first trimester; fetal hypoxia and bradycardia reported in late pregnancy and labour

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Interaction:

Warnings:

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Lactations:

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Counselling:

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Patient And Carer Advice: