Irbesartan + Hydrochlorthiazide

Indications & Dose:

• BY MOUTH

Adults:

Hypertension:

Initially 150mg/12.5mg once daily; increase if necessary to 300mg/12.5mg once daily or add other antihypertensives.

Renal disease: Initially 150mg once daily, titrate to 300mg once daily for maintenance.

Elderly: Over 75 years, consider starting dose of 75mg once daily then titrate according to response.

Children: Not recommended.

Contraindications:

 Pregnancy, lactation. Primary aldesteronism.

Side Effects:

Cautions:

Precautions:

 Correct volume and/or salt depletion before starting therapy. Renovascular hypertension. Renal impairment, heart failure, type II diabetes with renal disease; monitor serum potassium and/or creatinine levels. Aortic or mitral stenosis, obstructive hypertrophic cardiomyopathy, haemodialysis, severe hepatic impairment, recent kidney transplant

Interaction:

Potassium-sparing diuretics, potassium supplement, lithium, NSAIDs, aspirin.

Warnings:

Adverse Effects:

Dizziness, nausea, fatigue, increased plasma creatinine kinase. Orthostatic hypotension and dizziness, musculoskeletal pain, hyperkalaemia in type II diabetes with renal disease.

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: