Candesartan Cilexetil + Hydrochlorthiazide

Indications & Dose:

• BY MOUTH

Adult and Child >l6 yr:

Replacement therapy:

Combination product can be substituted for individual agents; maximum therapeutic effect would be expected within 4 weeks. Usual dosage range: Candesartan: 8-32 mg/day, given once daily or twice daily divided doses. Hydrochlorothiazide; 12.5-50mg once daily.

Children: Not recommended

PREGNANCY RISK Factor O/D (2nd and 3rd trimesters)

DOSAGE ADJUSTMENT IN RENAL IMPAIRMENT: Serum levels of candesartan are increased and the half-life of hydrochlorothiazide is prolonged in patients with renal impairment. Do not use if Clcr <30 mL/minute

DOSAGE ADJUSTMENT IN HEPATIC IMPAIRMENT: Use with caution

ELDERLY:

No initial dosage adjustment is recommended in patients with normal renal and hepatic function; some patients may have increased sensitivity

Contraindications:

Applicable which are observed for individual agents

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Lactations:

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Counselling:

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Patient And Carer Advice: