Famotidine

Indications & Dose:

Treatment of benign gastric and duodenal ulceration

• BY MOUTH

Adult: 40 mg once daily for 4–8 weeks, dose to be taken at night

Maintenance treatment of duodenal ulceration

• BY MOUTH

Adult: 20 mg once daily, dose to be taken at night

Reflux oesophagitis

• BY MOUTH

Adult: 20–40 mg twice daily for 6–12 weeks; maintenance 20 mg twice daily

Children: NOTE Treatment duration and dose should be individualized

Peptic Ulcer:

• BY MOUTH

1-16 years oral 0.5mg/kg/day at bed time or divided twice daily (max; 40mg/day.) doses of up to 1mg/ kg/day have been used. IV 0.25mg/kg every 24 hour ( max dose; 40mg/day doses up to 0.5mg/kg have been used

GRED:

• BY MOUTH

1less than 3 months oral 0.5mg/kg/day once daily . 3-5 months 0.5mg/kg twice daily. 1-6 year ; 1mg/ kg/day twice daily max; 40mg twice daily.

Heart Burn/Indigestion /Sour stomach: 

• BY MOUTH

Children more than 12 years and adults orally 10- 20mg every 12 hour taken 15-60 minutes before food. Neonates: more than 3 months iv 0.25-0.5mg/kg/ dose Q24 hr. Oral 0.5-1mg/kg/dose Q24 hr

Contraindications:

Hypersensitivity

Side Effects:

CNS: Anxiety, depression, dizziness, fever, headache, insomnia, paresthesia, seizures, somnolence

EENT: Orbital edema, taste change, tinnitus

GI: Abnormal liver enzymes, anorexia; constipation cramps, nausea, vomiting

HEME: Thrombocytopenia

MS: Arthralgia, myalgia

RESP: Bronchospasm

SKIN: Rash

Cautions:

Precautions:

Severe renal disease, severe hepatic function.

Pregnancy: & breast-feeding: Use with caution.

Old age: May be used.

Interaction:

Drugs

Cefpodoxime, cefuroxime, enoxacin, ketoconazole: Reduction in gastric acidity reduces absorption, decreased plasma levels, potential for therapeutic failure

Glipizide; glyburide; tolbutamide: Increased absorption of these drugs, potential for hypoglycemia

Nifedipine; nitrendipine; nisoldipine: Increased concentrations of these drugs

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: