Aprepitant

Indications & Dose:

Adjunct to dexamethasone and a 5HT3-receptorantagonist in preventing nausea and vomiting associated with moderately and highly emetogenic chemotherapy
BY MOUTH
Adult: Initially 125 mg, dose to be taken 1 hour befor
chemotherapy, then 80 mg once daily for 2 days, consult product literature for dose of concomitant corticosteroid and 5HT3-antagonist

Contraindications:

Acute porphyrias p. 930

Side Effects:

Common or very common Anorexia . asthenia . constipation . diarrhoea . dizziness . dyspepsia . headache . hiccupsUncommon Abdominal pain . abnormal dreams . acne .anaemia . anxiety . bradycardia . chills . colitis . confusion . conjunctivitis . cough . drowsiness . dry mouth . duodenal ulcer . dysuria . euphoria .flatulence . flushing . haematuria . hyperglycaemia . hyponatraemia . myalgia . neutropenia . oedema . palpitations . pharyngitis . photosensitivity .polyuria . pruritus . rash . sneezing . stomatitis . sweating .taste disturbance . thirst . tinnitus . weight changes Frequency not known Dysarthria . dyspnoea . insomnia . Stevens-Johnson syndrome . urticaria . visual disturbances
CONCEPTION AND CONTRACEPTION Effectiveness of hormonal contraceptives reduced—effective nonhormonal methods of contraception necessary during treatment and for 2 monthsafter stopping aprepitant.
PREGNANCY Avoid unless potential benefit outweighsrisk—no information available.
BREAST FEEDING Avoid—present in milk in animal studies.
HEPATIC IMPAIRMENT Caution in moderate to severeimpairment

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