Triamcinolone

Indications & Dose:

Suppression of inflammatory and allergic disorders

• BY DEEP INTRAMUSCULAR INJECTION

Adult: 40 mg (max. per dose 100 mg), repeated if necessary, dose given for depot effect, to be administered into gluteal muscle; repeated at intervals according to patient’s response

Contraindications:

Systemic fungal infections, bacterial infection of nose (nasal); primary treatment of status asthmaticus (inhalation).

Pregnancy & breast-feeding

Side Effects:

CNS: Depression, headache, mood changes, seizures, vertigo (systemic)

CV: CHF, hypertension, tachycardia

EENT: Blurred vision, Candida infection of oral cavity, cataract; dysphonia, hoarseness, increased intraocular pressure, sore throat (inhalation); dryness, epistaxis, nasal irritation and stinging, rebound congestion, sneezing (nasal)

GI:Abdominal distension, diarrhea, GI hemorrhage, increased appetite, nausea, pancreatitis

METAB: Cushingoid state, decreased glucose tolerance, growth suppression in children, HPA suppression

MS: Aseptic necrosis of femoral and humeral heads, fractures, muscle mass loss, osteoporosis, weakness

SKIN: Acne, allergic contact dermatitis, atrophy, bruising, burning, dryness, echymosis, folliculitis, hypectrichosis, hypopigmentation, irritation, itching. miliaria, perioral dermatitis, petechiae, poor wound healing, secondary infection (topical), striae; suppression of skin test reactions; thin, fragile skin

MISC: Systemic absorption of topical corticosteroids has produced reversible HPA axis suppression (more likely with occlusive dressings, prolonged administration, application to large surface areas, liver failure, and in children)

Cautions:

Precautions:

Psychosis, diabetes mellitus, glaucoma, osteoporosis, seizure disorders, ulcerative colitis (intestinal perforation), CHF, hypertension, myesthenia gravis (if .used with anticholinesterase agents), renal disease, esophagitis, peptic ulcer, latent tuberculosis or amebiasis (reactivation of disease).

Topical: use on face, groin, or axilla, ocular herpes simplex.

Old age: Use with caution

Interaction:

Drugs

Aminoglutethamide: Increased clearance of steroid; doubling of dose may be necessary

Antidiabetics: Increased blood glucose

Barbiturates, carbamazipine: Reduced serum concentrations of corticosteroids

Cholestyramine, colestipol: Possible reduced absorption of corticosteroids

Cyclosporine: Possible increased concentration of both drugs, seizures

Erythromycin, troleandomycin, clarithromycin, ketoconazole: Possible enhanced steroid effect

Estrogens, oral contraceptives: Enhanced effects of corticosteroids

lsoniazid: Reduced plasma concentrations of isoniazid

IUDs: Inhibition of inflammation may decrease contraceptive effect

NSAIDs: Increased risk of GI ulceration

Rifampin: Reduced therapeutic effect of corticosteroids

Salicylates: Increased elimination of salicylates

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: