Methylprednisolone Aceponate

Indications & Dose:

Endogenous eczema (atopic dermatitis, neurodermatitis), contact eczema, dyshidrotic and other eczemas.

DOSE AND DIRECTIONS FOR USE

For external use only.

Appropriate to the skin condition is applied thinly once per day to the diseased areas of skin. In general, the duration of use should not exceed 12 weeks in adults and 4 weeks in children. The respective bases are of major importance to the therapeutic effect of the Advantan formulations.

• Cream

As a low-fat formulation with a high water content, Cream is particularly suitable for acute and weeping stages of eczema, for very greasy skin and for use on exposed or hairy parts of the body. If the skin dries out excessively under protracted use of Cream, a switch should be made to one of the formulations (Advantan ointment or fatty ointment).

• Ointment

Skin conditions which are neither weepingnor very dry require a base with balanced proportions of fat and water. Ointment makes the skin slightly greasy without retaining warmith and fluid. Of the three formulations, Ointment has the widest field of use.

• Fatty ointment

Very dry skin conditions and chronic stages of skin diseases require an anhydrous base. The occlusive effect of the fatty ointment base promotes the healing procedure

Contraindications:

Tuberculous or syphilitic processes in the area to be treated; virus diseases (e.g., hyrpes simplex, vaccinia, chickenpox, shingles).

Corticosteroids have been shown to be teratogenic in animals following dermal application. As these agents are absorbed percutaneously, teratogenicity following topical application cannot be excluded. Should not be used during pregnancy

Side Effects:

Local concomitant symptoms such as itching, burning, erythema or vesiculation

The following side-effects may occur: folliculitis, hypertrichosis, perioral dermatitis, allergic skin reactions to one of the ingredients of the formulations.

Long-term continuous treatment with topical corticosteroids should be avoided as far as possible as this may cause atrophic changes in the skin leading to thinning, loss of elasticity, dilatation of superficial blood vessels, telangiectasiae and ecchymoses. These changes are particularly likely to occur on the face and when occlusive dressings are used. Acne form skin conditions can occur under therapy with potent corticoids

Systemic absorption of topically applied corticosteroids may occur, particularly under the following conditions: when large quantities are used, or when application is made to wide areas of the body, or to damaged skin, when potent topical corticosteroids are used, and when the occlusive dressing technique is applied. Depression of the hypothalamic-pituitary-adrenal axis with consequent suppression of the adrenal gland may occur. These effects are most likely to be severe in children. Growth may be retarded and a Cushingoid state may be produced. Benign increased intracranial pressure has been rarely reported

If a secondary microbial skin infection is present suitable concomitant antimicrobial therapy should be instituted. If fungal infections are present, a topically active antimycotic should be applied

Topical corticosteroids should be used with particular caution in facial dermatoses, and only for short periods. A steroid rosacea-like facies may be produced. If rosacea or perioral dermatitis is present, Advantan must not be applied to the face.

Should be used with caution in nursing mothers. Regular review should be made of the necessity for continuing therapy.

This corticosteroid preparation should not be used in the nappy areas in infants for flexural eruptions, and ideally it should not be applied to infants and young children.

The treatment of psoriasis with potent topical corticosteroids may provoke the pustular form of the disease.

Advantan should not be applied to skin crease areas

Cautions:

Precautions:

Interaction:

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: