Clinical Pharmacology Details


Tetanus Toxoid


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Indications & Dose:

Active immunisation against tetanus


DOSE 


For active primary immunization two doses of 0.5ml each by i.m. route at an interval of 4-6 weeks. Reinforcing dose should be given, 6-8 months later, to increase the level of immunity.


Booster dose: In previously immunized persons, a booster dose of 0.5ml i.m. should be given every 5 years to maintain adequate level of immunity. The need for tetanus vaccine in wound management depend both on the condition of the wound and immunisation history of the patient. For tetanus prone wound tetanus immunoglobulin may also be required.


For pregnant mothers by i.m. administration of two doses of 0.5ml starting in seventh month of pregnancy with an interval of four weeks. If immunization status is not known then three doses of TT should be given starting on sixth month with an interval of four weeks between each.

Contraindications:

Infant or children with evidence of acute illness. Defer during outbreak of poliomyelitis

Side Effects:

Mild local reactions, like pain, tenderness and induration at the site of injection.

Cautions:

Precautions:

Anaphylactic or hypersensitivity reaction. Individuals receiving corticosteroid or other immunosuppressive drugs

Interaction:

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: