Letrozole

Indications & Dose:

Treatment of advanced breast cancer in women with natural or artificially induced postmenopausal status, who have previously been treated with antiestrogens.

DOSE

Adult and elderly patients The recommended dose of is 2.5m once daily, continue until tumour progression is evident. No dose adjustment is required for elderly patients. Patients with hepatic and/or renal impairment. No dosage adjustment is required.

Children Not recommended

Contraindications:

Hypersensitivity to the active substance or to any of the excipients. Premenopausal endocrine status. During

pregnancy and lactation

Side Effects:

Headache, nausea, peripheral oedema, fatigue, hot flushes, hair thinning, rash,, vomiting, dyspepsia, weight increase. Musculoskeletal pain., anorexia leuko-rrhoea, constipation, dizziness, increased appetite, increased sweating, dyspnoea, thrombophlebitis, vaginal spotting, hyper-tension & pruritus

Cautions:

Precautions:

As letrozole is weakly bound to plasma proteins, it is anticipated that it could be removed from circulation by dialysis. The potential risk/benefit to such patients should be carefully considered before administration of femara.

Interaction:

Drugs

Patients receiving other commonly prescribed drugs (e.g. benzodiazepines; barbiturates;
NSAIDs such as diclofenac sodium, ibuprofen; paraceta-mol;
furosemide; omeprazole).

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: