Etoposide

Indications & Dose:

Small cell lung cancer. Acute monocytic and myelomonocytic leukemias. Hodgkin’s disease. Non-Hodgkin’s lymphoma & testicular tumours

DOSE

Adults Inj: 50-100mg/m2/daily for 5 days (infuse over 30- 60 mins); then 3-4 weeks treatment free; Small cell lung cancer 35mg/m2/day for 4 days. oral Star-ting dose: 100-200/m2/daily on days 1 to 5; then 3-4 weeks treatment free; take on empty stomach.

Children Not recommended

Contraindications:

Pregnancy and lactation. Severe hepatic dysfunction, acute infection, history of previous hypersensitivity. Severe bone marrow failure not due to malignant disease,severe hepatic dysfunction. 

Side Effects:

Myelosuppression, anorexia, stomatitis, reversible alopecia, flushing, nausea, vomiting, diarrhoea, allergic reactions, fever, hypotension, bone marrow depression, peripheral neuropathy, jaundice, bronchospasm.

Cautions:

Precautions:

Extravasation, infection, children, adequate contraception. Monitor hepatic, renal and haematological function.
Old age: May be used.

Interaction:

Drugs

Warfarin: Prolongation of prothrombin time may occur.

Other cytotoxic drugs: Synergism.

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: