Thioguanine

Indications & Dose:

Acute leukaemia | Chronic myeloid leukaemia l

• BY MOUTH

Adult: 100–200 mg/m2 daily, can be given at various stages of treatment in short-term cycles 

Contraindications:

Viraemic states; marrow aplasia; severe anaemia, leucopenia, thrombocytopenia; hepatic or renal failure.

Side Effects:

Cautions:

Precautions:

Haematological monitoring; infection. 

Interaction:

Mercaptopurine, busulfan, aminosal-icylates

Warnings:

Adverse Effects:

Hepatic dysfunction, leukopenia, thrombocytopenia, skin rash, hyperuricaemia, Gl upsets, unsteady gait.
PREGNANCY: Positive evidence of risk: Use only when no safer alternative exists for a serious problem

Lactations:

Contraindicated or not recommended.

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: