Mitoxantrone

Indications & Dose:

To reduce neurologic disability and frequency of relapses in patients with secondary (chronic) progressive, progressiv
e relapsing, or worsening relapsing-remitting multiple sclerosis (patients whose neurologic status is significantly abnormal between relapses) l

• BY I.V. INFUSION

Adults. 12 mg/m2 over 5 to 15 min every 3 mo.

Maximum: Cumulative dose of 140 mg/m2 .

As adjunct to treat pain related to advanced hormone-refractory prostate cancer 

• I.V. INFUSION

Adults. 12 to 14 mg/m2 over 5 to 15 min every 21 days.

As adjunct to treat acute nonlymphocytic leukemia (ANLL) l

• I.V. INFUSION

Adults. Initial: 12 mg/m2 over at least 3 min on days 1 to 3 with 100 mg/m2 of cytarabine as a continuous 24-hr infusion on days 1 to 7. If patient’s antileukemic response is inadequate or incomplete, second induction course is given at same dosage.

Maintenance: 6 wk after induction, 12 mg/ m2 over at least 3 min on days 1 and 2 with 100 mg/ m2 of cytarabine as a continuous 24-hr infusion on days 1 to 5. A second maintenance course is given 4 wk after the first if needed and tolerated.

Contraindications:

Hypersensitivity to mitoxantrone or its components

Side Effects:

Cautions:

Precautions:

Interaction:

DRUGS

allopurinol, colchicine, probenecid, sulfinpyr-azone:

Possibly interference with antihyper-uricemic action of these drugs blood-dyscrasia-causing drugs (such as ceph-alosporins and sulfasalazine): Increased risk of leukopenia and thrombocytopenia bone marrow depressants, such as carboplatin and lomustine: Possibly additive bone marrow depression daunorubicin,
doxorubicin: Increased risk of cardiotoxicity

methotrexate and other antineoplastics: Risk of developing leukemia vaccines, killed virus: Decreased antibody response to vaccine

vaccines, live virus: Increased risk of replication of and adverse effects of vaccine virus, decreased antibody response to vaccine

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Headache, seizures
CV: Arrhythmias, cardiotoxicity, chest pain, congestive heart failure, decreased left ventricular ejection fraction, EGG changes
EENT: Blue-colored cornea, conjunctivitis, mucositis, stomatitis
GI: Abdominal pain, diarrhea, GI bleeding, nausea, vomiting
GU: Blue-green urine, renal failure
HEME: Acute myelogenous leukemia, leukopenia, other leukemias, thrombocytopenia
MS: Myelodysplasia
RESP: Cough, dyspnea
SKIN: Alopecia, extravasation, jaundice
Other: Allergic reaction, anaphylaxis, hyperuricemia, infection, infusion-site pain or redness 

Patient And Carer Advice: