Pertuzumab

Indications & Dose:

Treatment of HER2-positive metastatic or locally recurrent unresectable breast cancer in combination with trastuzumab and docetaxel,n patients who have not received previous antiHER2 therapy or chemotherapy (initiated by a specialist) l

• BY INTRAVENOUS INFUSION

Adult: (consult product literature)

Contraindications:

Side Effects:

Common or very common Anaemia arthralgia chills constipation cough decreased appetite diarrhoea dizziness dry skin dyspepsia dyspnoea . febrile neutropenia . headache . increased lacrimation infusionrelated reactions . insomnia . left ventricular dysfunction leucopenia . malaise myalgia . nail disorder . nasopharyngitis neutropenia oedema pain paronychia peripheral neuropathy pleural effusion pruritus pyrexia . rash severe hypersensitivity reactions taste disturbance upper respiratory-tract infection Uncommon Interstitial lung disease Frequency not known Alopecia . bone-marrow suppression extravasation hyperuricaemia nausea oral mucositis thromboembolism tumour lysis syndrome vomiting

SIDE-EFFECTS Side effects mostly described for pertuzumab in combination with trastuzumab and docetaxel.

CONCEPTION AND CONTRACEPTION Ensure effective contraception during and for six months after treatment in women of childbearing potential. l

PREGNANCY Avoid (toxicity in animal studies). Most cytotoxic drugs are teratogenic and should not be administered during pregnancy, especially during the first trimester. Considerable caution is necessary if a pregnant woman presents with cancer requiring chemotherapy, and specialist advice should always be sought.

BREAST FEEDING Avoid—no information available.

HEPATIC IMPAIRMENT Caution—no information available.

RENAL IMPAIRMENT Caution in severe impairment—no information available.

Cautions:

Conditions that could impair left ventricular function . history of congestive heart failure . impaired left ventricular function . prior anthracycline exposure . radiotherapy to the chest area . recent myocardial infarction . serious cardiac arrhythmia . uncontrolled hypertension.

Precautions:

Interaction:

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: