Sorafenib

Indications & Dose:

Inhibitor of multiple kinase, use for treatment of advanced renal cell carcinoma, when treatment with interferon alfa or interleukin-2 has failed or is contraindicated. hepatocellular carcinoma. l

• BY MOUTH

Adult over 18 years, 400mg twice daily

Contraindications:

breast-feeding

Side Effects:

diarrhoea, constipation, dyspepsia, dysphagia, anorexia, hypertension, haemorrhage, flushing, hoarseness, fatigue, asthenia, depression, peripheral neuropathy, fever, erectile dysfunction, hypophosphataemia, arthralgia, myalgia, tinnitus, rash, pruritus, erythema, dry skin, desquamation, acne, hand-foot skin reaction; less commonly reversible posterior Ieucoencephalopathy, myocardial infarction, congestive heart failure, hypertensive crisis, and gastrointestinal perforations 

Cautions:

major surgical procedures; cardiac ischaemia; hepatic impairment ; pregnancy

Precautions:

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Patient And Carer Advice: