Oxaprozin

Indications & Dose:

Osteoarthritis, rheumatoid arthritis, prevention of cognitive decline,  acute gout,   pain mild to moderate, tendonitis/bursitis

• BY MOUTH

Adults:

600mg once a day.

In acute painful condition, Maximum

• BY MOUTH

Adults:

1200mg daily.

Children:

Not recommended.

Contraindications:

Bronchospasm, nasal polyps, angioedema precipitated by aspirin or other NSAIDs 

Side Effects:

Cautions:

Precautions:

History of GI ulceration, bleeding, or perforation; renal dysfunction, hypertension or cardiac conditions aggravated by fluid retention and edema, history of liver dysfunction, history of coagulation 

Interaction:

Drugs

Aminoglycosides: Reduced clearance with elevated aminoglycoside levels and potential for toxicity (especially indomethacin in premature infants; other NSAIDs probably)

Anticoagulants: Excessive hypoprothrombinemia, decreased platelet aggregation with increased risk of GI bleeding

Antihypertensives ( α -blockers, angiotensinconverting enzyme inhibitors, angiotensin ll receptor blockers, β -blockers, diuretics): Inhibition of antihypertensive and other favorable hemodynamic effects

Corticosteroids: Increased risk of GI ulceration

Cyclosporine: Increased nephrotoxicity risk

Lithium: Decreased clearance of lithium (mediated via prostaglandins) resulting in elevated serum lithium levels and risk of toxicity

Methotrexate: Decreased renal secretion of methotrexate resulting in elevated methotrexate levels and risk of toxicity

Phenylpropanolamine: Possible acute hypertensive reaction

Potassium-sparing diuretics: Additive hyperkalemia potential

Triamterene: Acute renal failure reported with addition of indomethacin; caution with other NSAIDs

Warnings:

Adverse Effects:

Lactations:

Pregnancy  ( if used in 3rd trimester); could cause constriction off the ductus arteriosus ire utero, persistent pulmonary hypertension of the newborn, or prolonged labor

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Dizziness, headache, lightheadedness
CV: Chest pain, CHF, dysrhythmias, edema, hypertension, hypotension, palpitation, tachycardia
EENT: Dry eyes, hearing disturbances, photophobia, tinnitus, visual disturbances
GI: Abdominal cramps, constipation, diarrhea, dyspepsia, flatulence, gastric or duodenal ulcer with bleeding oar perforation, hepatitis, nausea, occult blood in stool, pancreatitis, vomiting
GU: Acute renal failure
HEME: Agranulocytosis, eosinophilia, leukopenia, neutropenia, pancytopenia, thrombocytopenia
METAB: Hyperglycemia, hyperkalemia, hypoglycemia, hyponatremia
RESP: Bronchospasm, dyspnea, pulmonary infiltrates
SKIN: Photosensitivity, rash, urticaria 

Patient And Carer Advice: