Nimesulide

Indications & Dose:

Osteoarthritis, rheumatoid arthritis, low back pain, dysmenorrhoea  and other gynaecological disorders, dental and postoperative pain, in reducing pain of ear, nose and throat inflammation. Pain of malignancy, sports injuries.

• BY MOUTH
  

Adults

100mg bd.

Children

5mg/kg/day divided in 2 or 3 daily doses.

Contraindications:

Active peptic ulcer. Moderate to severe hepatic impairment.

PREGNANCY & BREAST-FEEDING: Contraindicated. 

Side Effects:

Nausea, vomiting, diarrhoea, heart burn, epigastric pain, pruritus, skin rash, headache, somnolence, dizziness. 

Cautions:

Precautions:

Renal impairment, heart failure.

Old Age: Use with caution

Interaction:

Drugs

Fenofibrate, Salicyclic acid, Valporic acid and Tolbutamide: These drugs displace nimesulide from the plasma binding sites.

Methotrexate and Frusemide: These drugs may be displaced from plasma proteins by nimesulide.

Warfarin: Exercise caution since efficacy may be increased.

Theophylline: Efficacy of slow release theophylline preparations reduced. 

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: