Clinical Pharmacology Details


Cyclobenzaprine


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Indications & Dose:

Muscle spasm associated with acute painful musculoskeletal conditions.
Adults: Initial: 5mg 3 times/day; may increase to 10 mg 3 times/day if needed. Do not use longer than 2-3 weeks.
Elderly: 5 mg 3 times/day.
Children: Not recommended. 

Contraindications:

Do not use concomitantly or within 14 days of MAO inhibitors; hyperthyroidism; congestive heart failure; arrhythmias; acute recovery phase of MI. 

Side Effects:

Cautions:

Precautions:

Cyclobenzaprine shares the toxic potentials of the tricyclic antidepressants and the usual precautions of tricyclic antidepressant therapy should be observed; use with caution in patients with urinary hesitancy, angle-closure glaucoma, hepatic impairment, or in the elderly. 

Interaction:

CPY1A2 inhibitors, TCAD, anticholinergics. CNS depressants, MAO inhibitors, tramadol. 

Warnings:

Adverse Effects:

Drowsiness, dizziness, xerostomia. 

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: