Baclofen

Indications & Dose:

Pain of muscle spasm in palliative care

• BY MOUTH

Adult: 5–10 mg 3 times a day

Hiccup due to gastric distension (in palliative care)

• BY MOUTH

Adult: 5 mg twice daily

Chronic severe spasticity resulting from disorders such as multiple sclerosis or traumatic partial section of spinal cord

• BY MOUTH

Adult: Initially 5 mg 3 times a day, gradually increased; maintenance up to 60 mg daily in divided doses, review treatment if no benefit within 6 weeks of achieving maximum dose; maximum 100 mg per day 

Contraindications:

Side Effects:

Cautions:

Precautions:

Peptic ulcer disease, renal disease, hepatic disease, stroke, seizure disorder, diabetes mellitus, elderly 

Interaction:

Warnings:

Adverse Effects:

Lactations:

Pregnancy category C; present in breast milk, 0. 1 % of mother’s dose; compatible with breast feeding 

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Disorientation, dizziness, drowsiness, fatigue, headache, insomnia, paresthesias, seizures (decreased seizure threshold); tremors; weakness

CV: Chest pain, edema, hypotension, palpitations

EENT: Blurred vision, mydriasis, nasal congestion, tinnitus

GI: Abdominal pain, anorexia, constipation, dry mouth, increased AST, alk phosphatase, nausea, vomiting

GU: Urinary frequency

METAB: Hyperglycemia

SKIN: Pruritus, rash

Patient And Carer Advice: