Colchicine

Indications & Dose:

Acute gout

• BY MOUTH

Adult: 500 micrograms 2–4 times a day until symptoms relieved, maximum 6mg per course, do not repeat course within 3 days continued’!

Short-term prophylaxis during initial therapy with all opurinol and uricosuric drugs

• BY MOUTH
  

Adult: 500micrograms twice daily

Prophylaxis offamilial Mediterranean fever (recurrent polyserositis)

• BY MOUTH
  

Adult: 0.5–2mg once daily 

Contraindications:

Serious GI, renal, hepatic, cardiac disorders; blood dyscrasias

Side Effects:

Cautions:

Precautions:

Elderly, lactation, children; may induce ileal vitamin B 12 malabsorption; extravasation may lead to shock 

Interaction:

Drugs
Cyclosporine,tacrolimus: Increased serum level of cyclosporine or tacrolimus

Erythromycin, clarithromycin,troleandomycin: Potential for severe colchicine toxicity 

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Peripheral neuritis
GI: Anorexia, cramps, diarrhea, malaise, metallic taste, nausea, vomiting
GU: Azotemia, hematuria, oliguria, reversible azoospermia
HEME: Agranulocytosis, aplastic anemia, pancytopenia, thrombocytopenia
MS: Myopathy (more common in persons with renal impairment)
SKIN: Alopecia, dermatitis, erythema, pruritus, purpura 

Patient And Carer Advice: