Albumin, Human

Indications & Dose:

 •Shock.

Adults: Initially, 500 m] (5% solution) by I.V. infusion; may repeat after 30 minutes. Dosage varies with patient’s condition and response. Maximum, 250 9 in 48 hours.
Children: 10 to 20 ml/kg (5% solution) by I.V. infusion, at up to 5 to 10 ml/minute.

• Hypoproteinemia.

Adults: 1,000 to 1,500 ml (5% solution) by I.V. infusion daily; maximum, 5 to 10 ml/minute or, 200 to 300 ml (25% solution) by I.V. infusion daily; maximum, 3 ml/ minute. Dosage varies with patient’s condition and response.

• Burns.

Adults and children: Dosage varies with extent of burn and patient’s condition. Usually, maintain plasma albumin level at 2 to 3 g/dl.

• Hyperbilirubinemia.

Infants: 1 g/kg albumin (4 ml/kg of 25% solution) by [.V. infusion 1 to 2 hours before transfusion. High-risk neonates with low serum protein levels: 1 .4 to 1.8 ml/kg (25% solution) by I.V infusion. 

Contraindications:

Contraindicated in patients hypersensitive to drug. Use with extreme caution in patients with hypertension, cardiac disease, severe pulmonary infection, severe chronic anemia, or hypoalbuminernia with peripheral edema. 

Side Effects:

Cautions:

Precautions:

Interaction:

Drug-drug.
ACE inhibitors: May cause atypical reactions when combined with plasma exchange of
large albumin volumes. Withhold ACE inhibitors for 24 hours before plasma exchange. 

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: fever, headache.
CV: hypotension, tachycardia, vascular overload after rapid infusion.
GI: increased salivation, nausea, vomiting.
Musculoskeletal: back pain.
Respiratory: altered respiration, dyspnea, pulmonary edema.
Skin: rash, urticaria.
Other: chills.

Effects on lab test results May increase albumin and alkaline phosphatase levels.
PEDIATRIC PATIENTS  Premature infants with low serum protein levels may receive 1.4 to 1.8 ml/kg of a 25% albumin solution/kg by I.V. infusion (350 to 450 mg albumin). 

Patient And Carer Advice: