TRIMEBUTINE MALEATE General properties same as peppermint.

Indications & Dose:

Treatment and relief of symptoms associated with the irritable bowel syndrome (spastic colon), and   - in postoperative paralytic ileus in order to accelerate the resumption of the  intestinal transit following abdominal surgery.

• BY MOUTH

Adult: Tab: is up to 600 mg daily in divided doses.  It is administered as one 200 mg tablet three times daily before meals.

Susp: 2-3 tsf. 3 to 4 times daily.

Contraindications:

Known  hypersensitivity to trimebutine maleate or any of the excipients. 

Side Effects:

Cautions:

Precautions:

Drug Interactions: Animal studies have shown that trimebutine maleate increases the duration of d-tubocurarine-induced curarization.  No other drug interactions have been observed during clinical trials or otherwise reported

Interaction:

Warnings:

Although teratological studies have not shown any drug related adverse effects on the course and outcome of pregnancy in laboratory animals by both oral and parenteral routes, the use in pregnant women is not recommended. 

Children:  Not recommended for use in children under 12 years of age. 

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Gastrointestinal: Dry mouth, foul taste, diarrhea, dyspepsia, epigastric pain, nausea and constipation were reported in total of 3.1% of the patient population; 

CNS: Drowsiness, fatigue, dizziness, hot/cold sensations and headaches were reported in 3.3%; 

Allergic reactions: Rash in 0.4% of the patients; 

Miscellaneous effects:  Menstrual problems, painful enlargement of breast, anxiety, urine retention and slight. 

Patient And Carer Advice: