Danazol

Indications & Dose:

Adults : •

• BY MOUTH

Dysfunctional uterine bleeding;,

200 mg daily for 3 months. Start on 1st day of menstrutation and continue without interruption

Children : Not recommended

• Fibrocystic breast disease:

• BY MOUTH

Initially 300mg daily for 3-6 months

• Mastalgia:

• BY MOUTH

100-400 mg daily for 6 months

• Gynaecomastia:

• BY MOUTH

400 mg daily for 6 months

Children, 200mg daily for 6 months, if no response after 2 months increase to 400mg daily

. • Endometrriosis;

• BY MOUTH

Start on 1st day of menstrutation and continue without interruption, 200-800mg daily for 6-9 months. Prior to ablation, 400-800mg daily for 3-6 weeks

Children: Not recommended.

Contraindications:

Side Effects:

CNS: Dizziness, emotional lability, fatigue, headache, nervousness, sleep disorders, tremor

CV: Elevated blood pressure

GI: Constipation, hepatic dysfunction (doses >400 mg/day), nausea, vomiting, pancreatitis

GU: Clitoral hypertrophy, hematuria, pelvic pain, testicular atrophy, menstrual irregularities (spotting, amenorrhea; cycle disturbances), vaginal dryness

METAB: Decreased HDL, increased LDL

SKIN: Acne, edema, flushing, mild hirsutism, oily skin or hair, sweating

MISC: Changes in libido, decrease in breast size, deepening of the voice, glucose intolerance, weight gain 

Cautions:

Precautions:

Interaction:

Drugs

Carbamazepine: Predictably increases serum carbamazepine concentrations, toxicity possible 

Cyclosporine: Increased serum cyclosporine concentrations, toxicity possible

HMG-CoA reductase inhibitors (lovastatin, pravastatin): Myositisrisk increased

Oral anticoagulants: Enhanced hypoprothrombinemic response

Tacrolimus: Increased tacrolimus concentrations, toxicity possible

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: