Mirabegron

Indications & Dose:

Urinary frequency, urgency, and urge incontinence

• BY MOUTH

Adult: 50 mg once daily 

Contraindications:

 Severe uncontrolled hypertension (systolic blood pressure 180mmHg or diastolic blood pressure 110 mmHg) 

Side Effects:

Common or very common Tachycardia . urinarytract infection

Uncommon Atrial fibrillation . dyspepsia . gastritis . hypertension . joint swelling . palpitation .pruritus 
rash vulvovaginal infection . vulvovaginal pruritus.

PREGNANCY Avoid—toxicity in animal studies.

BREAST FEEDING Avoid—present in milk in animal studies.

HEPATIC IMPAIRMENT Reduce dose to 25mg once daily in moderate impairment. Avoid in severe impairment—no information available.

RENAL IMPAIRMENT Reduce dose to 25 mg once daily if eGFR 15–29 mL/minute/1.73m2. Avoid if eGFR less than 15 mL/minute/1.73m2—no information available

Cautions:

History of QT-interval prolongation . stage 2 hypertension

Caution with concomitant use with drugs that prolong the QT interval.

HEPATIC IMPAIRMENT With concomitant use of strong cytochrome P450 inhibitors such as itraconazole, ketoconazole, ritonavir, or clarithromycin reduce dose to 25mg once daily in mild impairment, and avoid in moderate impairment.

RENAL IMPAIRMENT With concomitant use of strong cytochrome P450 inhibitors such as itraconazole, ketoconazole, ritonavir, or clarithromycin reduce dose to 25mg once daily if eGFR 30–89 mL/minute/1.73m2, and avoid if eGFR less than 30 mL/minute/1.73m2

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