Glibenclamide

Indications & Dose:

Non insulin dependent diabetes mellitus, NIDDM type-II.

• BY MOUTH

Adults: Initially 5mg daily. (elderly patient 2.5mg) as a single dose at breakfast adjusted according to response, max: 15mg daily.

Children: Not recommended.

Contraindications:

Pregnancy, diabetic coma, diabetic ketoacidosis, renal failure, hypersensi-tivity.

Side Effects:

Nausea, vomiting, epigastric discomfort, skin rash, urticaria, thrombocytopenia, leucopenia.

Cautions:

Precautions:

Strenous physical exercise, in underweight and taking irregu-lar meals can lead to hypoglycaemia.

Breast-feeding: Discontinue nursing or drug.

Old age: Use with caution.

Interaction:

Drugs

Hypoglyacemic effect of glibenclamide is enhanced by: Anticoagulants, Androgens, Chloramphenicol, Clofibrate, Fenfluramine, Fluconazole, Gemfibrozil, Histamine H2 antagonists, Magnesium Salts, Methyldopa, MAOIs, Phenylbutazone, Probenecid, Salicylates, Sulfinpyrazone, Sulfonamides, TCAs & Urinary acidifiers.

Hypoglycemic effect of glibenclamide inhibited by the following drugs: S-blockers, Cholestyramine, Diazoxide, Hydantoins, Rifampicin, Thiazide diuretics & Urinary alkalisers.

Charcoal: Reduces the absorption of glibenclamide thus reducing its efficacy of toxicity.

Digitalis glycosides: Co-administration results in increased digitalis serum levels.

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: