Cyproterone Acetate

Indications & Dose:

Prostate cancer

DOSE: 

Male hypersexuality, 50mg twice daily after food.

Contraindications:

(do not apply in prostate cancer) hepatic disease, severe diabetes (with vascular changes); sickle-cell anaemia, malignant or wasting disease, severe depression, history of thrombo-embolic disorders; youths under 18 years (may arrest bone maturation and testicular development).

Side Effects:

Fatigue and lassitude, breathlessness, weight changes, reduced sebum production (may clear acne), changes in hair pattern, gynaecomastia (rarely leading to galactorrhoea and benign breast nodules); rarely hypersensitivity reactions, rash and osteoporosis; inhibition of spermatogenesis (see notes above); hepatotoxicity reported (including jaundice, hepatitis and hepatic failure usually in men given 200-300 mg daily for prostatic cancer.

Cautions:

Ineffective for male hypersexuality in chronic alcoholism (relevance to prostate cancer not known); blood counts initially and throughout treatment; monitor hepatic function regularly (liver function tests should be performed before treatment, see also under Side-effects below); monitor adrenocortical function regularly; diabetes mellitus (see also Contra-indications)

Driving: Fatigue and lassitude may impair performance of skilled tasks (e.g. driving) 

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Counselling:

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