Tibolone

Indications & Dose:

Short-term treatment of symptoms of oestrogen deficiency (including women being treated with gonadotrophin releasing hormone analogues) | Osteoporosis prophylaxis in women at high risk of fractures when other prophylaxis contra-indicated or not tolerated

• BY MOUTH

Adult: 2.5 mg daily

Children: Not recommended 

Contraindications:

Hormone-dependent tumours, history of cardiovascular or cerebrovascular disease (e.g. thrombophlebitis, thromboembolism), uninvestigated vaginal bleeding, severe liver disease, pregnancy, breast-feeding.

Side Effects:

Weight changes, oedema, dizziness, seborrhoeic dermatitis, vaginal bleeding, headache, abdominal pain, gastro-intestinal disturbances, increased facial hair; depression, arthralgia, myalgia, migraine, visual disturbances, liver-function changes, rash and pruritus also reported

Cautions:

Renal impairment, epilepsy, migraine, diabetes mellitus, hypercholesterolaemia; withdraw if signs of thromboembolic disease, abnormal liver function tests or cholestatic jaundice. 

Precautions:

Interaction:

Drugs
Antibacterials Rifampicin: Accelerates metabolism (Reduced plasma concentration).

Antiepileptics : Carmazapine, phenobarbitone, phenytoin, primi-done : Accelerate metabolism

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: